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Apoptosis in Polymorphonuclear Cells and Inflammatory Cytokines of Trauma Patients

NCT03319017 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2018-01-04

No results posted yet for this study

Summary

This study tries to find how hypoxia and hyperoxia, among types of the respiratory failure induced cell damage that can arise in the course of traumatic damage and treatment, influences apoptosis of PMN cells and IL-6 and tumor necrosis factor(TNF)-α as inflammatory cytokines.

Conditions

Interventions

PROCEDURE

Multiple-trauma patients

The blood samples of the patients who agreed on this research are obtained in order to check their inflammatory response factor, and then their medical records are checked to find their initial ABGA result, lactate, C-reactive protein(CRP) known as initial inflammatory response, and procalcitonin. A patient's whole blood is collected in the tube with ethylene diaminetetracetic acid (EDTA) treatment. A modified method of Boyum's technique is applied so as to separate polymorphonuclear neutrophils. The separated polymorphonuclear neutrophils is collected so as to check apoptosis. And then, in the separated plasma, interleukin(IL)-6 and tumor necrosis factor(TNF)-α are measured, and its correlation with oxygen saturation will be analyzed.

Sponsors & Collaborators

  • Korea University

    collaborator OTHER

  • Korea University Guro Hospital

    lead OTHER

Principal Investigators

  • Jung-Youn Kim, MD, Ph.D. · Assistant Professor

Eligibility

Min Age
19 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-12-01
Primary Completion
2018-11-30
Completion
2018-11-30

Countries

  • South Korea

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03319017 on ClinicalTrials.gov