Effects of Dexmedetomidine on Respiratory Function and Inflammatory Responses in Patient With Sepsis Undergoing Cleaning Focus of Infection
NCT02842437 · Status: UNKNOWN · Phase: NA · Type: INTERVENTIONAL · Enrollment: 50
Last updated 2016-07-22
Summary
The purpose of this study is to assess the efficacy of dexmedetomidine on lung protection in patient with sepsis undergoing cleaning focus of infection.
Conditions
- Organ Protection
Interventions
- DRUG
-
dexmedetomidine
receive a loading infusion of dexmedetomidine (1ug/kg) for 10min follow by a maintenance infusion (0.5ug/kg·h) continued until the end of the surgery
- OTHER
-
normal saline
receive matching placebo (equal volume of normal saline)
Sponsors & Collaborators
-
General Hospital of Ningxia Medical University
lead OTHER
Principal Investigators
-
Zhang Yonghai · General Hospital of Ningxia Medical University
Study Design
- Allocation
- RANDOMIZED
- Purpose
- PREVENTION
- Masking
- DOUBLE
- Model
- PARALLEL
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2016-07-31
- Primary Completion
- 2017-12-31
- Completion
- 2017-12-31
Countries
- China
Study Locations
More Related Trials
-
Dendritic Cells-Derived Exosomes in Human Sepsis
NCT02957279 ·Status: UNKNOWN
-
Effect of Dexmedetomidine on Perfusion Index and Microcirculation in Severe Sepsis and Septic Shock Patients
NCT03151668 ·Status: UNKNOWN ·Phase: PHASE3
-
Early Goal Directed Sedation on Microcirculation in Septic Shock
NCT02612363 ·Status: UNKNOWN ·Phase: PHASE4
-
Clinical Trial to Evaluate MDW for Early Detection of Sepsis
NCT06267742 ·Status: ACTIVE_NOT_RECRUITING
-
Pharmacokinetics of XueBiJing in Patients With Sepsis
NCT03475732 ·Status: COMPLETED ·Phase: NA
-
Oral Administration or Nasal Feeding of Huzhangxiefei Decoction for Treatment in Sepsis Induced Acute Lung Injury
NCT04940676 ·Status: UNKNOWN ·Phase: PHASE2
-
Adjunctive Sedation With Dexmedetomidine for the Prevention of Severe Inflammation and Septic Encephalopathy
NCT04076826 ·Status: COMPLETED ·Phase: NA
-
Evaluation of the Effect of Dexmedetomidine on Phenylephrine Response During Refractory Septic Shock
NCT03953677 ·Status: TERMINATED ·Phase: PHASE3
-
Anisodamine Critically Ill SeptIc Shock
NCT02442440 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Safety and Efficacy of Early Administration of Dexamethasone in High-risk Sepsis
NCT05136560 ·Status: RECRUITING ·Phase: PHASE1/PHASE2
-
Neutrophil Elastase Inhibitor in Treatment of ARDS Patients With Mechanical Ventilation Caused by Sepsis
NCT05672472 ·Status: UNKNOWN ·Phase: NA
-
The Effect and Mechanism of lncRNA NBR2 Regulating Endothelial Pyroptosis by Targeting GSDMD in Sepsis
NCT04427371 ·Status: UNKNOWN
-
Efficacy of Anisodamine Hydrobromide Combined With Low-molecular-weight Heparin in the Treatment of Patients With Sepsis
NCT05634057 ·Status: RECRUITING ·Phase: NA
-
Novel Biomarkers Related Xuebijing Injection Improves Sepsis
NCT06920420 ·Status: NOT_YET_RECRUITING
-
Clinical Research on Shenfu Injection in Septic Patients
NCT06157320 ·Status: RECRUITING ·Phase: NA
-
The Efficacy of Xuebijing Injection on Sepsis
NCT03238742 ·Status: COMPLETED ·Phase: PHASE4
-
Emergency Department Management of Sepsis Patients: A Goal-Oriented Non-Invasive Sepsis Trial
NCT01453270 ·Status: COMPLETED ·Phase: NA
-
Metabolism of Branched-chain Amino Acids in Monocyte/Macrophage During Sepsis
NCT03842371 ·Status: UNKNOWN
-
Endotoxin Activity Assay and Microcirculation in Severe Sepsis
NCT02452138 ·Status: UNKNOWN
-
Efficacy and Safety of Methylene Blue in the Treatment of Severe Septic Shock
NCT06481410 ·Status: RECRUITING ·Phase: NA
-
Study on the Establishment of a System for Early Warning and Prognostic Evaluation of Patients With Sepsis
NCT05229328 ·Status: UNKNOWN
-
The Application of SERS and Metabolomics in Sepsis
NCT02213237 ·Status: UNKNOWN
-
Methylene Blue in Severe Sepsis and Septic Shock
NCT01797978 ·Status: UNKNOWN ·Phase: PHASE3
-
The PK/PD of Deoxycholic Acid Amphotericin B in Invasive Fungal Infection Patients With Sepsis/Septic Shock
NCT05642624 ·Status: COMPLETED
-
Clinical Outcome Study of High-dose Meropenem in Sepsis and Septic Shock Patients
NCT03344627 ·Status: COMPLETED ·Phase: NA