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Magnesium Sulphate for Attenuation of Hemodynamic Pressor Response After Myfield's Clamp Application

NCT03318471 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2017-10-24

No results posted yet for this study

Summary

Use of Mayfield skull clamp during craniotomies; results in a sharp and intense noxious stimulus which results in a severe hemodynamic pressor response. Many strategies have been reported to blunt this undesirable pressor effect. This prospective, double blind, and randomized study is the first to evaluate the effect of MgSo4 on attenuation of hemodynamic pressor activity after head clamp application during craniotomies.

Conditions

  • Supratentorial Brain Tumor

Interventions

DRUG

MgSo4

50 mg/kg MgSo4 in 100 ml 0.9 sodium Chloride 15 minutes prior to anesthesia induction over 15 minutes

DRUG

0.9% NaCl

100 ml 0.9% NaCl 15 minutes prior to anesthesia induction over 15 minutes

Sponsors & Collaborators

  • El-Sahel Teaching Hospital

    lead OTHER_GOV

Principal Investigators

  • Samir A ElKafrawy, MD · ElSahel Teaching hospital,Cairo

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-02-29
Primary Completion
2017-08-31
Completion
2017-10-01

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03318471 on ClinicalTrials.gov