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Simplified Isoniazid Preventive Therapy Strategy to Reduce TB Burden

NCT03315962 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 163

Last updated 2025-06-18

Study results available
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Summary

The overall objective of this study is to determine if a multi-component implementation intervention (SPIRIT) and additional leadership and management training that targets District Health Officers (DHOs) can increase IPT initiation among HIV-infected persons, as compared to country standard practices, in a cluster randomized trial in Uganda.

Conditions

Interventions

BEHAVIORAL

SPIRIT Intervention

The intervention will include implementing a teaching collaborative among group of DHOs and TB Supervisors, enabling text messaging between DHOs and front line providers, and establishing a report collaborative where DHOs will receive feedback on the performance of their district in administering IPT compared to other districts.

Sponsors & Collaborators

  • Makerere University

    collaborator OTHER

  • National Institute of Allergy and Infectious Diseases (NIAID)

    collaborator NIH

  • Cipla Ltd.

    collaborator INDUSTRY

  • University of California, San Francisco

    lead OTHER

Principal Investigators

  • Diane Havlir, MD · University of California, San Francisco

  • Gabriel Chamie, MD, MPH · University of California, San Francisco

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-11-15
Primary Completion
2023-11-30
Completion
2023-11-30

Countries

  • Uganda

Study Locations

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Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03315962 on ClinicalTrials.gov