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The Effects of Sedatives on Tobacco Use Disorder

NCT03813121 · Status: COMPLETED · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 10

Last updated 2022-10-06

Study results available
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Summary

This proposal will obtain preliminary data on the effect of a single sub-anesthetic dose of a sedative on cigarette craving and smoking behavior as well as measuring tolerability and acceptability.

Conditions

  • Tobacco Use Disorder

Interventions

DRUG

midazolam intravenous infusion

Participants will receive a single drug infusion

DRUG

placebo intravenous infusion

Participants will receive a single placebo infusion

DRUG

ketamine intravenous infusion

Participants will receive a single drug infusion

Sponsors & Collaborators

  • Wake Forest University Health Sciences

    lead OTHER

Principal Investigators

  • Merideth Addicott, PhD · University of Arkansas

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2019-06-01
Primary Completion
2021-08-31
Completion
2021-08-31
FDA Drug
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03813121 on ClinicalTrials.gov