MedTrace Logo

The Oral Microbiome and Upper Aerodigestive Squamous Cell Cancer

NCT03304132 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 560

Last updated 2017-10-09

No results posted yet for this study

Summary

The human oral cavity is a diverse habitat that contains approximately 700 prokaryotic species. The oral microbiome is comprised of 44% named species, 12% isolates representing unnamed species, and 44% phylotypes known only from 16S rRNA based cloning studies (http://www.homd.org/). Species from 11 phyla have been identified: Firmicutes, Bacteroidetes, Proteobacteria, Actinobacteria, Spirochaetes, Fusobacteria, TM7, Synergistetes, Chlamydiae, Chloroflexi and SR1 (http://www.homd.org/). Because these observations have been mainly based on data generated from traditional Sanger sequencing, the diversity of oral microbiome is highly likely underestimated. Application of high throughput sequencing to the oral microbiome similar to the scale of the microbiome studies of other body sites (GI tract, skin, and vagina) under the Human Microbiome Project is necessary to obtain data essential for understanding the diversity and community structure of the oral microbiome in health and disease.

Conditions

  • Oral Cancer

Interventions

OTHER

Classification of Oral Microbiome Using 16S rRNA gene sequence-based approach

The sequence-based approach is selected because it classifies samples by considering the entire difference (genetic distance) in 16S rRNA gene sequences among samples analyzed, unbiased by artificial details such as taxonomies, sequence length, or even quality scores.

OTHER

Classification of Oral Microbiome Using taxonomic approach

The taxonomic approach is a complement to the sequence-based approach in that it will further identify specific taxonomic groups or species that can explain the difference found by overall analyses.

Sponsors & Collaborators

Principal Investigators

  • Jiyoung Ahn, MD · NYU Langone Health

Eligibility

Min Age
40 Years
Max Age
92 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
1992-12-01
Primary Completion
2010-12-01
Completion
2010-12-01

Countries

  • United States

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03304132 on ClinicalTrials.gov