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Pregabalin Effects on Hypotensive Anesthesia During Spine Surgery.

NCT03301025 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 106

Last updated 2020-09-18

No results posted yet for this study

Summary

Elective lumbar spine surgical procedures are commonly performed under controlled hypotension during general anesthesia. That is beneficial to limit the intraoperative blood loss and transfusions and improves surgical field. Deliberate hypotension could be achieved via various medications but mostly associated with significant side effects. Pregabalin effectively augmented hypotensive anesthesia. The hypothesis is that Pregabalin 150 mg single preoperative dose may augment intraoperative deliberate hypotension that will be reflected on blood loss and nitroglycerin consumption.

Conditions

  • Spine Surgery

Interventions

DRUG

Pregabalin

Pregabalin 150 mg capsule, one h preinduction of general anesthesia

DRUG

placebo

given a placebo identical capsule once one hour before anesthesia

Sponsors & Collaborators

  • Mansoura University

    lead OTHER

Principal Investigators

  • Alaa Mazy · Faculty of Medicine, Mansoura University

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-01-08
Primary Completion
2018-03-30
Completion
2019-04-30

Countries

  • Egypt

Study Locations

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Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03301025 on ClinicalTrials.gov