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The Effect of Pregabalin Given Preoperatively on the Tourniquet Induced Ischemia-reperfusion

NCT03482544 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 54

Last updated 2018-11-19

No results posted yet for this study

Summary

The application of tourniquet is indispensable for a bloodless surgical area in total knee arthroplasty surgery. The release of tourniquet produces reactive oxygen species which can cause injury and then ischemia-reperfusion injury emerge. Our aim in this study is to investigate effects of pregabalin, GABA analog drug, on the tourniquet induced ischemia-reperfusion injury.

Conditions

  • Ischemia Reperfusion Injury

Interventions

DRUG

Pragabalin

pregabalin 150 mg will be given orally, 1 day and 1 hour before surgery (totally two times), patients in Pregabalin Group.

OTHER

Placebo

empty capsule will be given orally, 1 day and 1 hour before surgery (totally two times), patients in Control Group.

Sponsors & Collaborators

  • Baskent University

    lead OTHER

Principal Investigators

  • Omer Karaca, Assist.Prof · Baskent University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2018-10-10
Primary Completion
2018-10-30
Completion
2018-11-15

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03482544 on ClinicalTrials.gov