Proton Craniospinal Irradiation With Bone Sparing to Decrease Growth Decrement From Radiation
NCT03281889 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20
Last updated 2026-03-19
Summary
This research study is studying proton radiation as a possible treatment for brain tumor that requires radiation.
The radiation involved in this study is:
-Proton Radiation
Conditions
Interventions
- RADIATION
-
Proton Beam
precision radiation that reduce the negative effects radiation has on the surrounding non-cancerous growing and developing tissue
Sponsors & Collaborators
-
National Cancer Institute (NCI)
collaborator NIH -
Massachusetts General Hospital
lead OTHER
Principal Investigators
-
Shannon MacDonald, MD · Massachusetts General Hospital
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 3 Years
- Max Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2018-01-04
- Primary Completion
- 2027-06-30
- Completion
- 2027-12-31
- FDA Device
- Yes
Countries
- United States
Study Locations
More Related Trials
-
Proton Craniospinal Radiation Therapy vs. Partial Photon Radiation Therapy for Leptomeningeal Metastasis From Solid Tumors
NCT04343573 ·Status: COMPLETED ·Phase: PHASE2
-
Proton Beam Radiation Therapy for Central Nervous System (CNS) Germ Cell Tumors
NCT01049230 ·Status: ACTIVE_NOT_RECRUITING ·Phase: NA
-
Proton/Photon Rt - Benign Meningiomas(P92-13)
NCT02947984 ·Status: COMPLETED ·Phase: PHASE3
-
Proton Therapy for Chordomas and/or Chondrosarcomas
NCT00797602 ·Status: COMPLETED
-
Cognition-preserving Brain Irradiation for Treating Patients With Intracranial Meningioma in the Era of Modern Radiotherapeutic Techniques Including Proton Beam Therapy - a Prospective Study Focusing on Radiological Outcomes and Neurocognitive Endpoints
NCT05832099 ·Status: NOT_YET_RECRUITING
-
Proton Cranio-spinal Irradiation for Leptomeningeal Metastasis
NCT05746754 ·Status: RECRUITING ·Phase: NA
-
Neural Stem Cell Preserving Brain Radiation Therapy & Stereotactic Radiosurgery in Patients With 1-6 Brain Metastases
NCT00581113 ·Status: TERMINATED ·Phase: PHASE3
-
A Phase II Trial of Intensity-Modulated Proton Therapy for Incompletely Resected Craniopharyngioma and Observation for Craniopharyngioma After Radical Resection
NCT02792582 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
Hypofractionated Stereotactic Radiosurgery in Treating Patients With Large Brain Metastasis
NCT01705548 ·Status: COMPLETED ·Phase: NA
-
Trial of Proton Versus Carbon Ion Radiation Therapy in Patients With Chordoma of the Skull Base
NCT01182779 ·Status: UNKNOWN ·Phase: PHASE3
-
A-protein Levels in Adult and Pediatric Brain Tumor Patients
NCT00165542 ·Status: COMPLETED
-
SCRT Versus Conventional RT in Children and Young Adults With Low Grade and Benign Brain Tumors
NCT00517959 ·Status: UNKNOWN ·Phase: PHASE3
-
Spectroscopic MRI Guided Proton Therapy in Assessing Metabolic Change in Pediatric Patients With Brain Tumors
NCT04908709 ·Status: RECRUITING ·Phase: NA
-
HF-SRT vs. HS-WBRT in Treating Patients With Brain Oligometastases
NCT05807165 ·Status: NOT_YET_RECRUITING
-
Neurobehavioral Outcomes and Quality of Life in Pediatric Patients With Brain or Head/Neck Tumors Receiving Proton or Photon Radiotherapy
NCT02608762 ·Status: UNKNOWN
-
A Study for Image-Guided Radiation Therapy in Pediatric Brain Tumors and Side Effects
NCT00187226 ·Status: COMPLETED ·Phase: PHASE2
-
Observation or Radiation Therapy in Treating Patients With Newly Diagnosed Grade II Meningioma That Has Been Completely Removed by Surgery
NCT03180268 ·Status: RECRUITING ·Phase: PHASE3
-
Fractionated Stereotactic Radiosurgery for Large Brain Metastases
NCT02054689 ·Status: COMPLETED ·Phase: NA
-
Follow-Up Study of People Treated for Scoliosis
NCT02546479 ·Status: COMPLETED
-
Local Radiotherapy Following Complete Resection of a Brain Metastasis
NCT02729558 ·Status: TERMINATED ·Phase: NA
-
Neurocognitive Functioning With Genu-Sparing Whole Brain Radiation Therapy for Brain Metastases
NCT03223922 ·Status: RECRUITING ·Phase: NA
-
Management of Pediatric Craniopharyngioma by a Combination of Partial Surgical Resection, and Protontherapy (Craniopharyngioma)
NCT02842723 ·Status: COMPLETED ·Phase: PHASE2
-
Image Assisted Optimization of Proton Radiation Therapy in Chordomas and Chondrosarcomas
NCT04832620 ·Status: RECRUITING
-
Magnetic Resonance Imaging in Treating Children With Progressive Low-Grade Astrocytoma
NCT00005084 ·Status: UNKNOWN ·Phase: PHASE2
-
Long-term Cognitive and Functional Impact of Proton-therapy or Modern Fractionated Radiotherapy in Cavernous Sinus Meningioma: An Open-label Randomized 1:1 Phase III Study
NCT05895344 ·Status: RECRUITING ·Phase: NA