Treatment of Intermediate-stage Hepatocellular Carcinoma

Summary

The purpose of this study is to evaluate the efficacy and safety of transarterial chemoembolization (TACE) combined with arginine hydrochloride and trimetazidine hydrochloride tablets in the treatment of patients with hepatocellular carcinoma.

Conditions

• HCC

Interventions

DEVICE

Basic drugs therapy of HCC by TACE

Basic drugs include: 1. Molecular targeted drugs for HCC：apatinib; 2. Antiviral drugs (ETV or TDF) should be given to patients who were infected with HBV or HCV; 3. Patients with liver dysfunction should be treated with conventional hepatoprotective agents drugs (including glycyrrhizin, reduced glutathione, vitamin C，etc); 4. Patients with ascites symptoms should be treated with furosemide and spironolactone according to the urine volume, and they also should be treated with proton pump inhibitors in the prevention of gastrointestinal bleeding; 5. Other basic diseases were treated routinely.

DRUG

Arginine hydrochloride

Arginine hydrochloride injection 5g/dose; 40g/d; ivgtt; sustained medication for 24 days; drug withdrawal for 4 days.

DRUG

Trimetazidine hydrochloride

Trimetazidine hydrochloride, 20mg/tablet, 40mg, twice a day.

Sponsors & Collaborators

• First Affiliated Hospital of Xinjiang Medical University

  collaborator OTHER

• Luoyang Central Hospital

  collaborator OTHER

• Nanyang Central Hospital

  collaborator OTHER

• Anyang Tumor Hospital

  collaborator OTHER

• Shenma Medical Group General Hospital

  collaborator OTHER

• First People's Hospital of Shangqiu

  collaborator OTHER

• Jiaozuo third people's hospital

  collaborator UNKNOWN

• The First Affiliated Hospital of Zhengzhou University

  lead OTHER

Principal Investigators

• Zujiang Yu · The First Affiliated Hospital of Zhengzhou University

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

65 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-07-18

Primary Completion

2021-07-31

Completion

2021-07-31

Countries

• China

Study Locations