Treatment of Advanced Hepatocellular Carcinoma

Summary

The purpose of this study is to evaluate the efficacy and safety of arginine hydrochloride combined with trimetazidine hydrochloride tablets in the treatment of patients with hepatocellular carcinoma.

Conditions

• HCC

Interventions

OTHER

Basic drugs therapy of HCC

Basic drugs include: 1. Molecular targeted drugs for HCC：apatinib; 2. Antiviral drugs (ETV or TDF) should be given to patients who were infected with HBV or HCV; 3. Patients with liver dysfunction should be treated with conventional hepatoprotective agents drugs (including glycyrrhizin, reduced glutathione, vitamin C，etc); 4. Patients with ascites symptoms should be treated with furosemide and spironolactone according to the urine volume, and they also should be treated with proton pump inhibitors in the prevention of gastrointestinal bleeding; 5. Other basic diseases were treated routinely.

DRUG

Arginine hydrochloride

Arginine hydrochloride injection 5g/dose; 40g/d; ivgtt; sustained medication for 24 days; drug withdrawal for 4 days.

DRUG

Trimetazidine hydrochloride

Trimetazidine hydrochloride tablets 20mg/tablet, 40mg, twice a day.

Sponsors & Collaborators

• First Affiliated Hospital of Xinjiang Medical University

  collaborator OTHER

• Jiaozuo third people's hospital

  collaborator UNKNOWN

• Luoyang Central Hospital

  collaborator OTHER

• Nanyang Central Hospital

  collaborator OTHER

• Anyang Tumor Hospital

  collaborator OTHER

• Pingmei Shenma Medical Group General Hospital

  collaborator UNKNOWN

• First People's Hospital of Shangqiu

  collaborator OTHER

• The First Affiliated Hospital of Zhengzhou University

  lead OTHER

Principal Investigators

• Zujiang Yu, Pro,Dr · The First Affiliated Hospital of Zhengzhou University

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

65 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-07-18

Primary Completion

2021-07-31

Completion

2021-07-31

Countries

• China

Study Locations