MedTrace Logo

Fibre and Gas in Irritable Bowel Syndrome

NCT03265002 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 19

Last updated 2020-03-25

No results posted yet for this study

Summary

The aim of the study is to investigate how dietary fibre combinations affects gut physiology, particularly colonic gas production. Comparisons will be made between a single fermentable fibre (inulin), a non-fermentable fibre (psyllium) and a combination of the two. The study will also explore differences in response between diarrhoea-predominant and constipation-predominant IBS (IBS-D and IBS-C) respectively.

The participants will have a preliminary meeting to ensure they are eligible, then will attend the MRI department on 4 occasions separated by at least 1 week. They will ingest a drink with the fibre product mixed in, and will have 8 MRI scans (each lasting approximately 15 minutes).

Conditions

  • Irritable Bowel Syndrome

Interventions

DIETARY_SUPPLEMENT

Placebo

Ingestion of 500ml water with 50ml lemon juice and 20g dextrose

DIETARY_SUPPLEMENT

Inulin

Ingestion of 500ml water with 50ml lemon juice and 20g inulin

DIETARY_SUPPLEMENT

Psyllium

Ingestion of 500ml water with 50ml lemon juice and 20g psyllium

DIETARY_SUPPLEMENT

Inulin and psyllium

Ingestion of 500ml water with 50ml lemon juice and 20g inulin and 20g psyllium

Sponsors & Collaborators

  • University of Nottingham

    lead OTHER

Principal Investigators

  • Robin Spiller, Ph, BMBS · University of Nottingham

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
16 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-03-08
Primary Completion
2019-10-16
Completion
2019-10-16

Countries

  • United Kingdom

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03265002 on ClinicalTrials.gov