MedTrace Logo

Dynamics of Platelet Activation in Patients With Ventricular Assist Device (VAD)

NCT03255928 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 60

Last updated 2025-05-15

No results posted yet for this study

Summary

Consenting patients with end-stage heart failure that are implanted with/candidates for implant of a short-term/durable mechanical circulatory support device (e.g.: percutaneous microaxial pumps (Impella), extracorporeal membrane oxygenator (ECMO), Ventricular Assist Device (VAD) will be enrolled in the study.

Aim of the study is to evaluate the patients' haemostatic and coagulation profile, how it interacts with the support device as well as the effect of antithrombotic drugs. From these data, it will be possible to derive the mechanisms triggering post-implant thromboembolic/hemorrhagic complications and to identify potential therapeutic targets.

Conditions

  • Thrombosis
  • Blood Coagulation Disorder
  • Platelet Thrombus
  • Platelet Dysfunction Due to Aspirin
  • Failure;Ventricular

Interventions

DIAGNOSTIC_TEST

PAS assay, TGT

Evaluation of platelet function

Sponsors & Collaborators

  • Università Vita-Salute San Raffaele

    collaborator OTHER

  • Scientific Institute San Raffaele

    lead OTHER

Principal Investigators

  • Filippo Consolo, PhD · San Raffaele Scientific Institute

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-06-29
Primary Completion
2026-12-31
Completion
2026-12-31
FDA Device
Yes

Countries

  • Italy

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03255928 on ClinicalTrials.gov