MedTrace Logo

Comparative Study Between Airway Pressure Release Ventilation and Pressure Regulated Volume Control (PRVC) in Protective Lung Strategy as a Recruitment Maneuver for Severe ARDS Mechanically Ventilated Patients Using Lung Ultrasound Score

NCT07231107 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 90

Last updated 2025-12-03

No results posted yet for this study

Summary

The aim of this study is to elaborate on the effectiveness of recruitment maneuver by airway pressure release ventilation (APRV) as an open lung ventilatory strategy in comparison with PRVC mode in lung protective strategy regarding improvement of LUS score and P/F ratio in patients with severe ARDS

Conditions

  • ARDS (Acute Respiratory Distress Syndrome)

Interventions

PROCEDURE

Lung ultrasound

bedside lung ultrasound in six lung regions of interest, delineated by a parasternal line, anterior axillary line, posterior axillary line, and paravertebral line, are examined on each side. Each lung region is carefully examined in the longitudinal plane, and each intercostal space present in the region is examined in the transversal plane. The worst ultrasound pattern characterizes the region (regional LUS) using the following grading: 0 = normal aeration; 1 = moderate loss of aeration (interstitial syndrome, defined by multiple spaced B lines, or localized pulmonary edema, defined by coalescent B lines in less than 50% of the intercostal space examined in the transversal plane, or subpleural consolidations); 2 = severe loss of aeration (alveolar edema, defined by diffused coalescent B lines occupying the whole intercostal space); and 3 = complete loss of lung aeration (lung consolidation defined as a tissue pattern with or without air bronchogram)

Sponsors & Collaborators

  • Ain Shams University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-08-18
Primary Completion
2023-08-01
Completion
2024-07-01

Countries

  • Egypt

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07231107 on ClinicalTrials.gov