Meta-Analyses of Low-risk Lifestyle Behaviours and Patient Important Outcomes

Summary

Public health policy is universal in recommending the adoption of low risk low-risk lifestyle behaviors for health promotion and prevention of chronic or non-communicable diseases (NCDs).These behaviors generally include achieving and maintaining a healthy body weight, healthy diet, regular physical activity, smoking cessation, moderate alcohol intake, and adequate sleep. While there is a general consensus that adherence to any one of these low-risk lifestyle behaviors is associated with benefit, it is not clear if adherence to multiple behaviors would result in a larger benefit across different groups of people, conditions, and chronic disease outcomes. The Canadian Cardiovascular Society (CCS), as part of the Dyslipidemia Guidelines Update, commissioned a series of systematic reviews and meta-analyses (a type of knowledge synthesis) using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach to quantify the benefit of adherence to multiple low-risk lifestyle behaviors in relation to patient-important chronic disease outcomes (risk of cardiovascular disease, diabetes, cancer, and death) and assesses the quality and strength of the evidence for this benefit.

Conditions

• Cardiovascular Disease
• Diabetes
• Cancer
• Mortality

Interventions

BEHAVIORAL

Low-risk lifestyle behaviours

Low-risk lifestyle behaviours defined as: 1\) Healthy body weight (Minimum: BMI \<30kg/m2 or WC of \<88 in females or \<92 in males); 2) Healthy diet (healthy diet, diet score with higher fruits \& vegetables to Mediterranean dietary pattern); 3) Regular physical activity (20 minutes ≥ 1 time/week ); 4) Smoking cessation (never smoked to smoking cessation \>12 months); 5) Moderate alcohol intake (up to 30g/day); 6) Adequate sleep (\>6 hours)

Sponsors & Collaborators

• Canadian Institutes of Health Research (CIHR)

  collaborator OTHER_GOV

• The Physicians' Services Incorporated Foundation

  collaborator OTHER

• Canadian Diabetes Association

  collaborator OTHER

• Canadian Cardiovascular Society

  collaborator OTHER

• Banting & Best Diabetes Centre

  collaborator OTHER

• University of Toronto

  lead OTHER

Principal Investigators

• JOHN L SIEVENPIPER, MD, PHD, FRCPC · University of Toronto

Eligibility

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2016-06-30

Primary Completion

2017-12-31

Completion

2017-12-31

Countries

• Canada

Study Locations