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Gene Expression and Biomarker Profiling of Keloid Skin

NCT03228693 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 48

Last updated 2023-03-29

No results posted yet for this study

Summary

This study aims to examine both the genetic profile and the biomarkers implicated in keloid scar formation.

Hypothesis:

1. Differences in the genetic profiles of lesional and non-lesional skin contribute a given population's propensity to develop keloids
2. Differences in biomolecules expressed in subjects with and without keloids can help predict keloid occurrence and severity
3. Biomarker analysis will provide useful insights for future targeted therapies for keloid scars

Conditions

  • Keloid
  • Keloid of Ear Lobe
  • Healthy Adults

Interventions

PROCEDURE

Biopsy and/or triamcinolone injection

Subjects will have their blood drawn during the first study visit. Subsequently, a punch biopsy and/or triamcinolone injection will be given based on group timeline.

PROCEDURE

Excisional Biopsy

Complete excision of an earlobe keloid will be taken.

Sponsors & Collaborators

Principal Investigators

  • Roopal Kundu, M.D. · Northwestern University Feinberg School of Medicine

Study Design

Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
NONE
Model
SEQUENTIAL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-09-11
Primary Completion
2021-09-02
Completion
2023-01-31

Countries

  • United States

Study Locations

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Entities

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03228693 on ClinicalTrials.gov