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Autologous Oral Mucosa Transplantation for Limbal Stem Cell Deficiency

NCT03226015 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 27

Last updated 2017-07-21

No results posted yet for this study

Summary

PURPOSE: To report clinical and histochemical results of oral mucosa graft transplantation in eyes with limbal stem cell deficiency.

DESIGN: Prospective observational study.

METHODS: 32 eyes of 27 patients with limbal stem cell deficiency underwent direct oral mucosa graft transplantation with amniotic membrane transplantation with a mean follow-up of 19 months. Clinical course of the disease including emergency surgeries, planned curative procedures, conjunctival inflammation, acute inpatient treatment and best corrected visual acuity were assessed at 3 months postoperatively and at last follow up visit. The unneeded parts of oral mucosa graft were analyzed immunohistochemically with staining for mesenchymal stem cell markers and pericytes (CD 90, CD 146, CD 166, CD 31, CD 68, protein gene product).

Conditions

  • Limbal Stem-cell Deficiency

Sponsors & Collaborators

  • Institute of Anatomy TU Dresden

    collaborator UNKNOWN

  • Klinikum Chemnitz gGmbH

    lead OTHER

Principal Investigators

  • Katrin Engelmann, PhD · Klinikum Chemnitz

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-07-31
Primary Completion
2017-04-30
Completion
2017-05-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03226015 on ClinicalTrials.gov