MedTrace Logo

Characterization of Diseases With Salivary Gland Involvement

NCT02327884 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 1150

Last updated 2026-05-22

No results posted yet for this study

Summary

Background:

\- Salivary glands in and around the mouth and throat make saliva. Salivary gland disorders can affect a person s quality of life. Studying people who have a disease that affects their salivary gland(s) may teach researchers about the disorders and their genetics.

Objectives:

\- To study salivary gland diseases and disorders. To collect data and samples from people with salivary gland problems and their relatives.

Eligibility:

* People more than 4 years old who have or are suspected to have a disease involving salivary glands.
* Their relatives more than 4 years old.
* Healthy volunteers 18 years or older.

Design:

* Participants may be screened with:
* Medical history
* Physical exam
* Blood and urine tests
* General oral and dental history and exam
* Saliva collection
* Eye exam and test for dry eyes
* Health questionnaires (adults)
* Biopsy of some minor salivary glands. A small incision will be made on the inside of the lower lip and several tiny salivary glands will be removed.
* Participants will have 2-3 visits. These may include:
* Repeats of some screening tests
* Ultrasounds of some glands. Researchers will put some gel on the face, then press on it with a smooth wand.
* Adults may have other biopsies
* A small catheter inserted into the opening of the parotid gland duct on the inside of the cheek. A saline solution (in a syringe) will fill the duct.
* Swishing a saltwater solution in the mouth for 10 seconds and then spitting into a cup
* Scrapings collected from teeth, tongue, and cheeks

Conditions

  • Healthy Volunteer
  • Sjogren's Syndrome
  • Salivary Gland Disease

Sponsors & Collaborators

  • National Institute of Dental and Craniofacial Research (NIDCR)

    lead NIH

Principal Investigators

  • Margaret E Beach, P.A.-C · National Institute of Dental and Craniofacial Research (NIDCR)

Eligibility

Min Age
4 Years
Max Age
100 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-04-03
Primary Completion
2032-04-01
Completion
2032-04-01

Countries

  • United States

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02327884 on ClinicalTrials.gov