Effect of Body Weight Loading on Urinary Electrolyte Excretion

Summary

Title: Effect of body weight loading on urinary electrolyte excretion

Swedish Title: Effekt av belastning på utsöndring av elektrolyter

Study period: Q2-Q3 2017

Study site: The study will be performed at the Institution for Neurology and Physiology, Sahlgrenska Academy, University of Gothenburg. Principal Investigator is John-Olov Jansson, MD, PhD, Professor at Institute of Neuroscience and Physiology, University of Gothenburg

Background and study design: Weight reduction can be obtained by decreased appetite or increased metabolism. However, acute weight loss can also be obtained by loss of fluids - for example by increased urinary loss of fluid and salts, so called elctrolytes. Preliminary results from a laboratory lesson for the Master of Science in Medicine program at University of Gothenburg suggest that carrying a 10 kg weight vest could increase urinary excretion of Na+, K+ and Cl-. The purpose of this study is to investigate this further in a more controlled research setting. If confirmed, the results could potentially contribute to the development of potent diuretics or obesity medicines.

The study will include 15 healthy volunteers and consist of three study days with about one week between each study day. The study subjects will go through a different study procedure each study day, and a randomized cross-over study design will be used to determine which procedure each day.

Procedure 1: Wearing a weight vest with 10 % of body weight standing for seven hours. The study subject is allowed to sit for 10 minutes each hour. The reason for this is that it has been considered that the effect may be transmitted by weight loading of the lower extremities.

Procedure 2: Wearing a weight vest with 1 % of body weight standing for seven hours, as a control for procedure 1, with lower loading. The study subject is allowed to sit for 10 minutes each hour.

Procedure 3: Wearing a weight vest with 1 % of body weight sitting for seven hours. This is a procedure with even less loading of the lower extremities than during procedure 2.

Urine- and blood samples, as well as heart rate and blood pressure measurements, will be collected during the study days and analyzed in order to address the primary and secondary objectives of the study.

Conditions

• Obesity
• Edema

Interventions

OTHER

Heavy Casall HIT weight vest

A weight west with a weight of 10 % compared to the study subject

BEHAVIORAL

Standing

Study subjects will be standing for at least 50 minutes every hour

DIETARY_SUPPLEMENT

Water load

Study subjects will drink 5 ml per kg body weight at the start of experiment and continue drinking the same volume as excreted by the kidneys during the experiment

BEHAVIORAL

Sitting

Study subjects will be sitting for at least 50 minutes of every hour

OTHER

Light Casall HIT weight vest

A weight west with a weight of 1 % compared to the study subject

Sponsors & Collaborators

• Sahlgrenska University Hospital

  collaborator OTHER

• Göteborg University

  lead OTHER

Principal Investigators

• John-Olov Jansson · Univeristy of Gothenburg

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2017-06-13

Primary Completion

2017-07-04

Completion

2017-07-04

Countries

• Sweden

Study Locations