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The Effects of General Anesthetics on Lymphocytes in Patients Undergoing Colorectal Cancer Resection and Mechanism Involved

NCT03193710 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 260

Last updated 2017-11-06

No results posted yet for this study

Summary

The body immunity is important to the development of tumor. The immune system is in charge of monitoring and cleaning tumor cells in circulation. Anesthesia may alter the immune response and affect the elimination of tumor cells. The purpose of the trial is to test whether inhalational anesthetic is relevant to tumor metastasis and recurrence of patients undergoing colorectal cancer resection through depression of lymphocytes-mediated immunity.

Conditions

  • Colorectal Cancer Metastatic
  • Survival Rate
  • General Anesthetics Toxicity
  • Lymphocyte Destruction
  • Molecular Mechanism of Pharmacological Action

Interventions

DRUG

Propofol

Propofol will be used for anesthesia maintenance in the total intravenous anesthesia group.

DRUG

Sevoflurane

Sevoflurane will be used for anesthesia maintenance in the inhalation anesthesia group.

DRUG

Remifentanil

Remifentanil will be used for analgesia in both groups.

Sponsors & Collaborators

  • Guizhi Du

    lead OTHER

Principal Investigators

  • Jin Liu, MD, PhD · Department of Anesthesiology, West China Hospital

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-09-01
Primary Completion
2018-10-31
Completion
2023-10-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03193710 on ClinicalTrials.gov