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DPP4 Activity, Microvascular Reactivity and Inflammation

NCT03178019 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 52

Last updated 2017-06-08

No results posted yet for this study

Summary

Dipeptidyl peptidase 4 (DPP4) is a serine exopeptidase able to inactivate various oligopeptides involved in inflammation, immunity and vascular function. Our aim was to investigate the associations between constitutive levels of DPP4 activity and inflammatory biomarkers, skin microvascular reactivity, gut peptides, insulin resistance indexes, heart rate and blood pressure variability, and measures of adiposity in subjects with different grades of glucose tolerance.

Conditions

  • Overweight
  • Pre Diabetes
  • Diabetes Mellitus Type 2 Without Complication

Interventions

OTHER

Laser-Doppler methods

This was a cross-sectional study in which participants were subjected to a screening phase before being eligible to participate in the study. All subjects were submitted to Laser-Doppler methods (assessment of microcirculatory blood flow), bioimpedance analysis (assessment of body composition), venous blood collections (laboratory analysis), and Finometer Pro (assessment of heart rate variability and blood pressure variability).

Sponsors & Collaborators

  • Rio de Janeiro State University

    lead OTHER

Principal Investigators

  • Wellington S Silva Júnior, MD · State University of Rio de Janeiro

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2014-02-01
Primary Completion
2015-12-01
Completion
2016-12-01

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03178019 on ClinicalTrials.gov