Austrian Registry on the Outcome of Monochorionic Pregnancies

Summary

About one third of twin pregnancies are resulting from a single fertilized oocyte. Two third of these monozygotic twins share a common placenta and are therefore called monochorionic. Due to placental sharing and the ever-present inter-fetal vascular connections, specific complications may arise and lead to an increased risk of intrauterine death and long-term neurodevelopmental impairment. Specific complications include twin-to-twin transfusion syndrome (TTTS), twin-anemia-polycythemia sequence (TAPS), selective intrauterine growth restriction (sIUGR) and discordant major anomalies, occurring in about 10%, 5%, 20% and 6% of monochorionic diamniotic twins. Prenatal interventions may improve perinatal and long-term outcome of affected fetuses. However, general knowledge about early diagnosis of monochorionic twins and their specific complications is still limited in a significant number of practitioners in Austria and systematic analysis of pregnancy outcomes are not conducted.

In this prospective multicenter registry study, the investigators aim to include all monochorionic pregnancies in Austria. Main outcome parameter is the occurrence of complications. Secondary outcomes are gestational age at occurrence of complications, gestational age delivery and neonatal outcome. The investigators also strive for long-term outcome, especially of infants following complicated pregnancies or preterm birth.

Conditions

• Twin Dichorionic Diamniotic Placenta
• Twin Monochorionic Monoamniotic Placenta
• Twin-To-Twin Transfusion Syndrome
• Twin Pregnancy With Antenatal Problem

Sponsors & Collaborators

• Medical University of Vienna

  collaborator OTHER

• Medical University Innsbruck

  collaborator OTHER

• Johannes Kepler University of Linz

  collaborator OTHER

• Paracelsus Medical University

  collaborator OTHER

• Klinikum Klagenfurt am Wörthersee

  collaborator OTHER

• Brothers of Saint John of God Eisenstadt

  collaborator UNKNOWN

• SMZ-Ost Donauspital

  collaborator OTHER

• Hospital Hochsteiermark

  collaborator UNKNOWN

• Landesklinikum Sankt Polten

  collaborator OTHER

• Klinikum Wels-Grieskirchen

  collaborator OTHER

• Landeskrankenhaus Feldkirch

  collaborator OTHER

• Landesklinkum Wiener Neustadt

  collaborator OTHER

• Mödling Hospital

  collaborator OTHER

• Medical University of Graz

  lead OTHER

Principal Investigators

• Philipp Klaritsch, MD · Department of Obstetrics and Gynecology, Medical University of Graz, Austria

Eligibility

Min Age

18 Years

Max Age

50 Years

Sex

FEMALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2017-05-01

Primary Completion

2025-01-31

Completion

2025-01-31

Countries

• Austria

Study Locations