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The DNA Methylation of ARHGEF11 in Macrosomia

NCT03165643 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 239

Last updated 2017-05-24

No results posted yet for this study

Summary

Background Macrosomia at birth is associated with subsequent susceptibility to obesity, abnormal glucose metabolism, hypertension and dyslipidaemia. Epigenetic reprogramming has been reported to be involved in the development of human diseases caused by suboptimal environmental or nutritional factors.

Objective The study was aiming to explore epigenetic mechanism influences on macrosomic infants exposed to intrauterine hyperglycemia.

Design The investigators performed a genome-wide analysis of DNA methylation in cord blood from macrosomic infants born to women with gestational diabetes or infants with normal birth weight born to normal glucose-tolerant women in order to identify genes related to foetal growth or early adipose tissue development. The candidate genes were then validated using SEQUENOM MassARRAY after bisulfite conversion.

Conditions

  • Gestational Diabetes
  • Diabetes
  • Macrosomia, Fetal

Interventions

DIAGNOSTIC_TEST

OGTT

75 g glucose tolerance test was provided to all pregnant women during 24-28 weeks.

Sponsors & Collaborators

  • Peking University First Hospital

    lead OTHER

Eligibility

Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-03-06
Primary Completion
2014-10-18
Completion
2014-10-18

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03165643 on ClinicalTrials.gov