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Cognitive Changes After Major Joint Replacement - Full Trial (Cognigram 2)

NCT03147937 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 505

Last updated 2025-09-05

No results posted yet for this study

Summary

Patients assume that cognitive performance rapidly returns to baseline after anesthesia and surgery. Several studies have shown that one week after major non-cardiac surgery about 27% of patients have postoperative cognitive dysfunction (POCD) and 10% of patients at 3 months. Very few studies have assessed the incidence of POCD beyond 3 months. POCD significantly reduces quality of life. Identifying risk factors for POCD is important because it is associated with prolonged hospital stay, loss of independence, and premature retirement. There is an urgent need to measure and document the level of cognitive change associated with surgery with an easy to use tool, both prior to admission and after discharge. This information can be used to plan appropriate care paths and to identify or test the efficacy of potential new treatments to alter the negative trajectory.

Conditions

Interventions

OTHER

Cognitive Testing

Computerized CogState Brief Battery (CBB), Cognigram, assesses changes in four cognitive domains including psychomotor function, attention, learning and memory, and working memory. The CBB is a computerized test based on card games that can be administered online

Sponsors & Collaborators

  • Dr. Stephen Choi

    lead OTHER

Principal Investigators

  • Stephen Choi, MD,FRCPC,MSc · Sunnybrook Research Institute

Eligibility

Min Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-05-01
Primary Completion
2025-12-31
Completion
2025-12-31

Countries

  • Canada

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03147937 on ClinicalTrials.gov