A Study of Memory, Thinking, and Brain Imaging in Adults With Histiocytosis

Summary

The purpose of this study is to try to understand how histopcytosis can cause symptoms or problems in the brain. The tests being done in the study will look at memory and thinking as well as brain function via MRI scan.

Conditions

• Histiocytosis

Interventions

BEHAVIORAL

Trail Making Test, Parts A & B

Part A is a timed measure of visual scanning and graphomotor speed. Part B is a timed measure of cognitive flexibility.

BEHAVIORAL

Brief Test of Attention

Assesses auditory working memory

BEHAVIORAL

Symbol Span

Assesses visual working memory

BEHAVIORAL

Controlled Oral Word Association Test

The COWA timed test of phonemic verbal fluency. It requires the subject to generate as many words as possible, beginning with a given letter of the alphabet (i.e., F, A, and S).

BEHAVIORAL

The Hopkins Verbal Learning Test-Revised

HVLT-R is a test of verbal learning and memory. Scores obtained are the total number of words.

BEHAVIORAL

Brief Visuospatial Memory Test-Revised

The BVMT-R is a test of visuospatial learning and memory.

BEHAVIORAL

Hospital Anxiety and Depression Scale

The HADS is a brief assessment validated in many cancer populations.

BEHAVIORAL

McGill Quality of Life Scale

This is a questionnaire that is a validated 17-item QOL instrument validated for ill patients and in the particular context of the ancer.

DIAGNOSTIC_TEST

MR Brain Imaging

Standard of care brain MR imaging includes high-resolution 3D T1-weighted images in the axial plane. The axial T1-weighted images will be isotropic with a typical matrix size of 256 x 256, 256 mm field-of-view (FOV) and 1 mm slice thickness covering the whole brain.

DIAGNOSTIC_TEST

Resting state functional MRI

Scanning will be performed on a 3 Tesla General Electric scanner (Optima 750W) with a GEM HNU 24-channel head coil. rsFMRI matching the FLAIR and T1 post-contrast images will be obtained. For resting state fMRI, T2\*-weighted images will be acquired with a single-shot gradient echo echo-planar imaging (EPI) sequence in the axial orientation (TR = 2500 ms, TE = 30 ms, FA = 80°, slice thickness = 4 mm, FOV= 240mm2, matrix=64×64) covering whole brain. For the resting state fMRI portion of the scan, patients will be instructed by the technologist or research staff to leave eyes open, focus on looking at a crosshair, and not think about anything during the scan.

BEHAVIORAL

Functional Assessment of Cancer Therapy Cognitive Scale (FACT-Cog)

This is a validated 37-item QOL instrument for cancer patients with cognitive complaints. The measures consist of FACT-Cog total, perceived cognitive impairments, perceived cognitive abilities, and impact on quality of life.

Sponsors & Collaborators

• Memorial Sloan Kettering Cancer Center

  lead OTHER

Principal Investigators

• Eli Diamond, MD · Memorial Sloan Kettering Cancer Center

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-04-07

Primary Completion

2027-04-30

Completion

2027-04-30

FDA Device

Yes

Countries

• United States

Study Locations