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TLR4 Polymorphisms and Risk of Skin Cancer

NCT03122366 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 392

Last updated 2023-03-22

No results posted yet for this study

Summary

Toll-like receptors (TLRs) play a key role in the innate immune system. Toll-like receptor-4 (TLR4) in particular, appears to play a role in susceptibility to cancer. Of 44 identified SNPs (small nucleotide polymorphisms) in TLR4, the most common is an A-G substitution at nucleotide position +896, downstream of the cDNA start codon, a missense mutation which leads to an amino acid substitution Asp299Gly in the third exon of the TLR4 gene. Pre-clinical studies from our laboratory have shown an association of TLR4 with ultraviolet radiation induced skin cancer. Hence, in this study we will assess the pattern of TLR4 polymorphisms and susceptibility to skin cancer.

Conditions

Interventions

DIAGNOSTIC_TEST

Detection of single nucleotide polymorphisms (SNP)

Asp299Gly SNP in the third exon of the TLR4 gene will be detected in blood

Sponsors & Collaborators

  • University of Alabama at Birmingham

    lead OTHER

Principal Investigators

  • Nabiha Yusuf · University of Alabama at Birmingham

Eligibility

Min Age
50 Years
Max Age
99 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2009-02-02
Primary Completion
2011-09-27
Completion
2011-09-27

Countries

  • United States

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03122366 on ClinicalTrials.gov