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Early Healing of Oral Soft Tissues: a Clinical and Biomolecular Analysis. Part II

NCT04276129 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 3

Last updated 2021-03-01

No results posted yet for this study

Summary

The purpose of the present study is to evaluate the influence of the post-surgical chlorhexidine indication in the gene expression profile and cellular behavior in the early wound healing process -24 hours after injury- of the oral soft tissues.

The main hypothesis is that the post-surgical use of chlorhexidine affects the gene expression and the celular behavior in the early wound healing process of the soft oral tissues.

Conditions

  • Wound Heal
  • Wound Surgical
  • Oral Soft Tissue Conditions
  • Chlorhexidine Adverse Reaction

Interventions

PROCEDURE

periodontal surgery + 24 hr buccal attached gingiva (G) biopsy

Periodontal surgery will be performed and 24 hr after the surgical procedure a 2mm punch biopsy will be harvested at the level of the buccal attache gingiva (G).

OTHER

post-surgical CHX mouth-rinses indication

CHX mouth-rinses (0.12%) will be indicated 2 times/day after the surgical procedure

Sponsors & Collaborators

  • University of Roma La Sapienza

    lead OTHER

Principal Investigators

  • Andrea Pilloni, MD,DDS,MS · University of Roma La Sapienza

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
30 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2020-02-20
Primary Completion
2020-10-17
Completion
2020-10-17

Countries

  • Italy

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT04276129 on ClinicalTrials.gov