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Effect of Acetazolamide on Intraocular Pressure After Being in the Trendelenburg Position.

NCT03107429 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 9

Last updated 2017-04-11

No results posted yet for this study

Summary

Perioperative vision loss following laparoscopic colorectal surgery is rare but has been reported. Studies show Trendelenburg positioning during surgery can produce a significant rise in the IOP, and this rise is thought to be a possible factor. Acetazolamide decreases IOP by reducing the formation of aqueous humour.

Aims:

To investigate if acetazolamide reduces the IOP rise resulting from Trendelenburg positioning.

Methods:

A randomised cross-over blinded pilot study. Nine healthy volunteers were randomised to start with the placebo or Acetazolamide with a 5 days' washout period. Baseline IOP was measured on both days. After 1.5 hours of taking the medication, volunteers lay head-down at 17 degrees' for 4 hours and IOP measurements repeated. This reading was subtracted from the baseline to give a 'change in IOP'.

Conditions

  • IOP

Interventions

DRUG

Acetazolamide

Acetazolamide tablets were placed in capsules to make them look similar to placebo.

DRUG

Placebo

Placebo was a sugar based placebo placed in a capsule.

OTHER

Trendelenburg Position

Placed in Trendelenburg Position

Sponsors & Collaborators

  • University of Nottingham

    lead OTHER

Principal Investigators

  • Parveen Vitish-Sharma, MRCS MSc · NDDC BRU

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-03-01
Primary Completion
2015-10-01
Completion
2015-10-01

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03107429 on ClinicalTrials.gov