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Determination of Coronarphysiological Parameters With the Method of Thermodillution

NCT03101696 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2019-03-26

No results posted yet for this study

Summary

The gold standard to induce coronary hyperemia for measurement of fractional flow reserve (FFR), coronary flow reserve (CFR) and index of microcirculatory resistance (IMR) is adenosine, but it exerts several side effects due to its unspecific action on adenosine receptors. The specific A2a-receptor agonist, regadenoson, has been shown to dilate coronary arteries and enables FFR measurements. The aim of the study was to evaluate whether simultaneous measurement of FFR, CFR and IMR is feasible, safe and effective within regadenoson-induced hyperemia.

Conditions

  • Coronary Artery Stenosis of Unclear Hemodynamic Relevance

Sponsors & Collaborators

  • Heinrich-Heine University, Duesseldorf

    lead OTHER

Principal Investigators

  • Malte Kelm, MD · Division of Cardiology, Pulmonary Disease and Vascular Medicine

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-02-05
Primary Completion
2019-02-28
Completion
2019-02-28

Countries

  • Germany

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03101696 on ClinicalTrials.gov