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Immunity to Hepatitis B Vaccine

NCT03083158 · Status: COMPLETED · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 16

Last updated 2020-11-25

No results posted yet for this study

Summary

Infection and cancer is a major cause of death and morbidity, and may be preventable through vaccination. It is not fully understood at the molecular level why some people respond better than others to vaccines until now the technology to assess this has not been available. This has impaired vaccine development. The overall goal of the Human Vaccines Project is to understand the 'rules' of how vaccines work. In this demonstration project the investigators will vaccinate healthy adults with hepatitis B vaccine to start to understand better how it works, ultimately helping with rational vaccine design in the future.

Conditions

Interventions

DRUG

Hepatitis B vaccine

1.0 ml (20 micrograms) suspension of hepatitis B surface antigen for intramuscular injection

Sponsors & Collaborators

  • Vanderbilt University

    collaborator OTHER

  • J. Craig Venter Institute

    collaborator OTHER

  • The Scripps Research Institute

    collaborator OTHER

  • University of California, San Diego

    collaborator OTHER

  • Institut Pasteur

    collaborator INDUSTRY

  • Human Vaccines Project

    collaborator OTHER

  • University of British Columbia

    lead OTHER

Principal Investigators

  • Manish Sadarangani · University of British Columbia

  • Tobi Kollmann · University of British Columbia

Study Design

Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
40 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-03-06
Primary Completion
2018-02-01
Completion
2018-02-01

Countries

  • Canada

Study Locations

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Entities

Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03083158 on ClinicalTrials.gov