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The Boston Circulatory Arrest Study: Antecedents and Correlates of Well-Being in Adults With Congenital Heart Disease

NCT03073122 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 127

Last updated 2023-08-16

No results posted yet for this study

Summary

In the landmark Boston Circulatory Arrest Study, neurologic and developmental status was measured following infant heart surgery and then prospectively at ages 1, 2.5, 4, 8, and 16 years, with findings of significant neurocognitive deficits and brain MRI abnormalities regardless of operative management. To date, no study has evaluated the neuropsychological and neuroimaging antecedents and correlates of well-being in adults with congenital heart disease, a population now \>1 million and projected to grow at 5% per year. The investigators propose to study the Boston cohort at ages 24-29 years to assess the associations of adult well-being with childhood and adolescent executive function, other measures of mental health and cognitive function, adolescent brain MRI findings, and clinical variables; findings will guide the design of interventions in childhood to optimize outcomes in adults with congenital heart disease.

Conditions

  • Transposition Great Arteries
  • Executive Dysfunction

Interventions

DIAGNOSTIC_TEST

Brain MRI, neurocognitive and psychological testing

MRI of the brain and multiple tests of neurocognitive and psychological function including executive function, anxiety and depression

Sponsors & Collaborators

Principal Investigators

  • Michelle Gurvitz, MD · Boston Children's Hospital

Eligibility

Min Age
24 Years
Max Age
33 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-11-09
Primary Completion
2021-11-01
Completion
2023-01-31

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03073122 on ClinicalTrials.gov