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Multiple Sclerosis: The Role of Mitochondrial Dysfunction in IR Resistance

NCT03052595 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 70

Last updated 2023-04-12

No results posted yet for this study

Summary

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease of the central nervous system (CNS) and is one of the most common neurological diseases, often leading to disability of the patients. The MS pathogenesis includes vascular and inflammatory components, however recently also the role of mitochondrial dysfunction being a hot topic in neurodegeneration.

Conditions

Interventions

DIAGNOSTIC_TEST

Oral glucose tolerance test

Oral glucose tolerance test to measure glucose and insulin concentrations after oral glucose load

DIAGNOSTIC_TEST

Testing of autonomous nervous system function

Autonomous nervous system function will be assessed using a battery of tests (orthostasis, Valsalva manoeuvre, heart rate variability recording, blood hormone levels, ect.)

DIAGNOSTIC_TEST

Stroop test

Stroop test will be used to test cognitive function

Sponsors & Collaborators

  • Comenius University

    collaborator OTHER

  • Slovak Academy of Sciences

    lead OTHER_GOV

Principal Investigators

  • Viera Sevcikova, Ing · Biomedical Research Center of Slovak Academy of Sciences

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-02-01
Primary Completion
2023-03-31
Completion
2023-03-31

Countries

  • Slovakia

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03052595 on ClinicalTrials.gov