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Transplantation Efficacy of Autologous Bone Marrow Mesenchymal Stem Cells With Intensive Atorvastatin in AMI Patients

NCT03047772 · Status: UNKNOWN · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 124

Last updated 2018-01-25

No results posted yet for this study

Summary

The benefit of current stem cell transplantation therapy for myocardial infarction is limited by low survival rate for stem cell. The purpose of this study is to test whether intensive Atorvastatin therapy can improve the outcome of patients with impaired left ventricle function after acute myocardial infarction who underwent intracoronary transfer of autologous bone marrow mesenchymal stem cells.

Conditions

Interventions

DRUG

Transplantation

Optimal dose autologous Bone Marrow Mesenchymal Stem Cells transplantation

DRUG

Atorvastatin

Routine dose of Atorvastatin therapy

DRUG

Intensive Atorvastatin

Intensive dose of Atorvastatin therapy

DRUG

Low dose BMMSC

Low dose autologous Bone Marrow Mesenchymal Stem Cells transplantation

DRUG

Middle dose BMMSC

Middle dose autologous Bone Marrow Mesenchymal Stem Cells transplantation

DRUG

High dose BMMSC

High dose autologous Bone Marrow Mesenchymal Stem Cells transplantation

Sponsors & Collaborators

  • Peking Union Medical College Hospital

    collaborator OTHER

  • The First Hospital of Hebei Medical University

    collaborator OTHER

  • Zunyi Medical College

    collaborator OTHER

  • Yuejin Yang

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
FACTORIAL

Eligibility

Min Age
30 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-03-06
Primary Completion
2018-12-31
Completion
2018-12-31

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Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03047772 on ClinicalTrials.gov