Cell Therapy in Myocardial Infarction

Summary

The purpose of this study is to determine cell therapy efficacy in patients with ST elevation acute myocardial infarction (STEMI)

Conditions

• Acute Myocardial Infarction

Interventions

PROCEDURE

Autologous Bone Marrow Mononuclear Cells (ABMMC) Transplantation

Catheter based stem cells delivery of 100 million cells resuspended in a 10 ml solution of saline with autologous serum. About 100 ml of Bone Marrow aspirate were harvested from iliac crest between the fifth and seventh day after myocardial infarction. ABMMC were isolated by density gradient centrifugation on Ficoll-PaqueTM plus (Amersham Biosciences) and manipulated under aseptic conditions for injection, after being filtered through 100 um nylon mesh to remove cell aggregates.

Sponsors & Collaborators

• Pro-Cardiaco Hospital

  collaborator OTHER

• Hospital do Coracao

  collaborator OTHER

• Instituto Estadual de Cardiologia Aloysio de Castro

  collaborator UNKNOWN

• Hospital Cardiológico Costantini

  collaborator UNKNOWN

• Hospital Universitário Regional do Norte do Paraná - FUEL

  collaborator UNKNOWN

• Hospital Santa Izabel

  collaborator OTHER

• Hospital Santa Izabel de Sergipe

  collaborator UNKNOWN

• Hospital Agamenon

  collaborator UNKNOWN

• Hospital do Andaraí

  collaborator UNKNOWN

• Hospital de Messejana

  collaborator UNKNOWN

• Hospital de Clinicas de Porto Alegre

  collaborator OTHER

• Faculty of Medicine of Ribeirão Preto (FMRP-USP)

  collaborator OTHER

• Instituto Nacional de Cardiologia de Laranjeiras

  collaborator OTHER

• Instituto de Cardiologia do Rio Grande do Sul

  collaborator OTHER

• Hospital São Marcos

  collaborator UNKNOWN

• Hospital Universitário Oswaldo Cruz - UPE

  collaborator UNKNOWN

• Real Hospital Português de Beneficência

  collaborator UNKNOWN

• Hospital Municipal Miguel Couto

  collaborator OTHER

• Anis Rassi Hospital, Brazil

  collaborator OTHER

• Federal University of São Paulo

  collaborator OTHER

• Instituto Dante Pazzanese de Cardiologia

  collaborator OTHER

• Universidade Federal do Rio de Janeiro

  collaborator OTHER

• Hospital Bandeirantes

  collaborator OTHER

• InCor Heart Institute

  collaborator OTHER

• Hospital Santa Isabel de Blumenau

  collaborator UNKNOWN

• Federal University of Uberlandia

  collaborator OTHER

• Hospital TotalCor

  collaborator OTHER

• Hospital de Clínicas Mario Lioni

  collaborator UNKNOWN

• Hospital de Clínicas de Niteroi

  collaborator UNKNOWN

• Ministry of Health, Brazil

  lead OTHER_GOV

Principal Investigators

• Hans F Dohmann, MD · PROCEP/Pró-Cardíaco Hospital

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Model

PARALLEL

Eligibility

Min Age

30 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2006-07-01

Primary Completion

2014-01-21

Completion

2014-07-14

Countries

• Brazil

Study Locations