Patient-Centered NeuroRehabilitation (PCN)

Summary

As individuals grow older, a number of factors can reduce our cognitive (or thinking) abilities such as "normal" aging, neurodegenerative diseases, and cardiovascular disease. This study will evaluate whether cognitive rehabilitation and transcranial electrical stimulation (TES) can improve cognitive abilities. Cognitive rehabilitation refers to methods that are used to improve tasks people have trouble doing in everyday life. Transcranial electrical stimulation uses small amounts of electricity to try to alter brain functioning. These approaches may help improve cognitive abilities like attention, learning, memory, finding words, and problem solving as well as everyday functioning. The goal of this study is to identify how to best use these methods, either alone or in combination.

Conditions

• Cognitive Deficit

Interventions

DEVICE

Active tDCS

Participants will receive active tDCS at up to 4mA per electrode for up to 40 minutes for up to 260 sessions.

DEVICE

Sham tDCS

Participants will receive sham tDCS for up to 260 sessions

BEHAVIORAL

Cognitively based intervention

Participants may receive a cognitively based intervention that targets the particular cognitive and/or functional abilities of interest. This includes methods of cognitive training, cognitive remediation, and cognitive rehabilitation for up to 260 sessions

DEVICE

Active tACS

Participants will receive active transcranial alternating current stimulation at up to 4mA per electrode for up to 40 minutes for up to 260 sessions

DEVICE

Sham tACS

Participants will receive sham transcranial alternating current stimulation for up to 260 sessions

DEVICE

Active tRNS

Participants will receive active transcranial random noise stimulation at up to 4mA per electrode for up to 40 minutes for up to 260 sessions

DEVICE

Sham tRNS

Participants will receive sham transcranial random noise stimulation for up to 260 sessions

Sponsors & Collaborators

• University of Michigan

  lead OTHER

Principal Investigators

• Benjamin M Hampstead, Ph.D. · University of Michigan

Study Design

Allocation

NON_RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

50 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2016-06-30

Primary Completion

2027-11-30

Completion

2027-11-30

Countries

• United States

Study Locations