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Hereditary Gastric Cancer Syndromes: An Integrated Genomic and Clinicopathologic Study of the Predisposition to Gastric Cancer

NCT03030404 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 733

Last updated 2026-05-22

No results posted yet for this study

Summary

Background:

Gastric cancers are cancers of the stomach. Hereditary ones are passed from parent to child. Researchers want to gather data about hereditary gastric cancers. They want to learn about changes these cause in the body and about the genes involved.

Objective:

-To gather data about hereditary gastric cancer.

Eligibility:

* People at least 2 years old with personal or family history with a hereditary gastric cancer.
* People at least 2 years old with gene changes that lead to such cancer or a lesion that may be hereditary.

Design:

* Participants will be screened in a separate protocol.
* Participants will have:

* Physical exam
* Medical history
* Blood tests
* Scans
* Photos of skin lesions and other findings
* Gynecology consultation for women
* Cheek swab (some participants)
* For some participants, their relatives will be asked to join the study.
* Some participants will be asked to allow the study to get stored tissue samples for relatives who have died.
* Some samples will be sent to outside labs. All personal data will be protected. Samples will be destroyed when the study ends.
* Participants will get the results of genetic testing.
* Participants who cannot come to the NIH clinic may just give a cheek swab and have genetic testing done.
* Some participants will be contacted for more testing.

Conditions

  • Stomach Neoplasms
  • Stomach Cancer
  • Gastric Adenocarcinoma and Proximal Polyposis of the Stomach (GAPPS)
  • Hereditary Diffuse Gastric Cancer (HDGC)
  • Familial Diffuse Gastric Cancer

Sponsors & Collaborators

  • National Cancer Institute (NCI)

    lead NIH

Principal Investigators

  • Andrew M Blakely, M.D. · National Cancer Institute (NCI)

Eligibility

Min Age
2 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-01-27
Primary Completion
2025-03-31
Completion
2025-03-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03030404 on ClinicalTrials.gov