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Perioperative Endothelial Dysfunction in Patients Undergoing Major Acute Abdominal Surgery

NCT03010969 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 224

Last updated 2021-02-17

No results posted yet for this study

Summary

The aim of the clinical study is:

1. to examine the association between postoperative endothelial function, indirectly measured by reactive hyperemia index, and major adverse cardiovascular events including myocardial injury and cardiac death within 30, 90 and 365 days of acute abdominal surgery.
2. to examine the association between postoperative endothelial function, indirectly measured by reactive hyperemia index, and non-cardiovascular complications including non-cardiac death within 30, 90 and 365 days of acute abdominal surgery.
3. to examine the importance of the postoperative blood glucose level and the pulmonary function for postoperative complications and death within 30, 90 and 365 days of acute abdominal surgery.
4. to examine the association between postoperative endothelial function, pulmonary function and blood glucose level
5. the qualitative part of the study will examine the postoperative subjective symptoms including acute and chronic pain, quality of recovery and functional status, depressive thoughts and post-traumatic stress disorder.

Conditions

  • Cardiovascular Complication
  • Complication, Postoperative

Interventions

PROCEDURE

Acute abdominal surgery

Acute abdominal surgery within 72 hours of admission to the department of surgery

Sponsors & Collaborators

  • Zealand University Hospital

    lead OTHER

Principal Investigators

  • Sarah Ekeloef, MD · Department of Surgery, Zealand University Hospital

  • Jakob Burcharth, MD, Phd. · Department of Surgery, Zealand University Hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-10-31
Primary Completion
2018-11-30
Completion
2019-11-30

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03010969 on ClinicalTrials.gov