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RNA and Heat Shock Protein Biomarkers in Radiation-induced Fibrosis in Breast Cancer

NCT03000764 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2018-08-08

No results posted yet for this study

Summary

The purpose of this study is to seeking a molecular signature of pathological radiation induced fibrosis based on the response of skin fibroblasts after irradiation, comparing two groups of patients distinguished by their individual radiosensitivity. The signature will integrate recent insights in terms of alternative splicing of mRNAs and level of expression of non-coding RNAs, particularly long non-coding RNAs, snRNAs, snoRNAs and microRNAs. In each group each expression patterns of candidate HSP proteins potentially predictive of pathological radiation induced fibrosis (HSP27, HSP70, αβ crystalline) in the serum and on cell culture will be characterized.

Conditions

Interventions

OTHER

skin biopsies

Biopsies (12 G) will be performed : * in non-irradiated breast skin * in irradiated breast skin

OTHER

blood samples

blood samples are collected: * 10 ml in EDTA tube * 2,5 ml in PAXgene Blood RNA tube * 4 ml in EDTA tube

Sponsors & Collaborators

  • Institut de Cancérologie de Lorraine

    lead OTHER

Principal Investigators

  • VOGIN GUILLAUME, MD, PhD · Institut de Cancérologie de Lorraine

  • BEHM-ANSMANT Isabelle, PhD · UMR 7365 CNRS-Université de Lorraine, IMoPA

Study Design

Allocation
NA
Purpose
OTHER
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-05-10
Primary Completion
2018-04-18
Completion
2018-04-25

Countries

  • France

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03000764 on ClinicalTrials.gov