Multi-Center Study of Different Doses Domperidone in Feeding Intolerance

Summary

The purpose of this clinical multi-center study is to determine whether different doses of domperidone are effective in the treatment of feeding intolerance in premature infant

Conditions

• Feeding Intolerance
• Premature Birth
• Domperidone Overdose
• Gastric Retention

Interventions

DRUG

Low dose

0.2mg group-The premature infant will be fed with 0.2mg/kg/tds domperidone and will be tested the residual glucose everyday in a 7-days period.

DRUG

normal dose

0.4mg group-The premature infant will be fed with 0.4mg/kg/tds domperidone and will be tested the residual glucose everyday in a 7-days period.

DRUG

over dose

0.6mg group-The premature infant will be fed with 0.6mg/kg/tds domperidone and will be tested the residual glucose everyday in a 7-days period.

DRUG

Glucose

Glucose group-The premature infant will be fed with glucose and will be tested the residual glucose everyday in a 7-days period.

Sponsors & Collaborators

• Guangdong Provincial Maternal and Child Health Hospital

  collaborator OTHER

• Shen-Zhen City Maternity and Child Healthcare Hospital

  collaborator OTHER

• Maternal and Child Health Hospital of Foshan

  collaborator OTHER

• Guangzhou Panyu Central Hospital

  collaborator OTHER

• Nanfang Hospital, Southern Medical University

  lead OTHER

Principal Investigators

• WeiMing Huang, professor · Nanfang Hosiptal

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Model

CROSSOVER

Eligibility

Min Age

20 Weeks

Max Age

35 Weeks

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2015-11-30

Primary Completion

2017-05-31

Completion

2017-06-30

Countries

• China

Study Locations