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Thiamine vs. Placebo to Increase Oxygen Consumption After Cardiac Arrest

NCT02974257 · Status: TERMINATED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 41

Last updated 2025-04-10

Study results available
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Summary

This study is to evaluate whether thiamine can increase oxygen consumption and lower lactate in patients who initially survive an in-hospital cardiac arrest. Patients who are successfully resuscitated after an in-hospital cardiac arrest and who are on mechanical ventilation in the intensive care unit will be enrolled, and will get either thiamine or placebo. Their oxygen consumption and lactate will be measured at serial time points and compared between groups. The investigators' hypothesis is that thiamine will help restore the body's ability to metabolize oxygen normally (aerobic metabolism), leading to an increase in oxygen consumption and a decrease in lactate.

Conditions

  • Cardiac Arrest
  • Shock
  • Lactic Acidosis
  • Thiamin Deficiency

Interventions

DRUG

Thiamine

Thiamine 500mg IV twice daily for 2 days

OTHER

placebo

100mL normal saline IV every 12 hours for 2 days

Sponsors & Collaborators

Principal Investigators

  • Katherine M Berg, MD · Beth

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-05-01
Primary Completion
2022-02-07
Completion
2022-08-01
FDA Drug
Yes

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02974257 on ClinicalTrials.gov