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NEUROIMPA - Intraarticular Application of Opioids in Chronic Arthritis of the Knee Joint

NCT02967302 · Status: UNKNOWN · Phase: PHASE2/PHASE3 · Type: INTERVENTIONAL · Enrollment: 112

Last updated 2021-08-03

No results posted yet for this study

Summary

To investigate pain and inflammatory parameters (cytokines, immune cells) in knee joint tissue of chronic arthritis patients following intraarticular (i.a.) injections of morphine, a standard steroid or placebo.

The primary hypothesis is that i.a. morphine results in significantly lower pain scores and supplemental analgesic consumption than placebo during the first week after injection, an efficacy comparable to standard i.a. steroid (triamcinolone) medication.

Conditions

  • Knee Arthritis

Interventions

DRUG

Morphine Sulfate

active intervention

DRUG

Triamcinolone

active control

DRUG

placebo

placebo control

Sponsors & Collaborators

  • DLR German Aerospace Center

    collaborator OTHER

  • Hildrun Haibel

    lead OTHER

Principal Investigators

  • Hildrun Haibel, PD Dr · Charité CBF, Rheumatology, Berlin, Germany

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-08-31
Primary Completion
2021-12-31
Completion
2021-12-31

Countries

  • Germany

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02967302 on ClinicalTrials.gov