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Comparison of Efficacy of Intra-articular Morphine vs Methylprednisolone in Patients With Knee Osteoarthritis.

NCT06163755 · Status: WITHDRAWN · Phase: PHASE2 · Type: INTERVENTIONAL

Last updated 2023-12-11

No results posted yet for this study

Summary

Prospective randomized double-blind controlled study. Participating patients with knee pain secondary to knee osteoarthritis will be randomized to either the DepoMedrol 40mg + 0.25% Bupivacaine (total Volume 5 ml) vs Morphine 3mg group+0.5% Bupivacaine (total volume 5ml) for their intra-articular knee injection. Before the injections, baseline values of NRS (Numerical rating scale) and WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) Questionnaire will be recorded by investigator. After the injections NRS and WOMAC will be recorded at 30mins and on discharge. Patient will be contacted by phone to assess the effectivity of block or any side effects on day 1, 7,30 and 45, information including NRS (at rest and household activity), WOMAC, supplemental analgesic, Side effects (pruritus, paresthesia, urinary retention, nausea, vomiting, dizziness, rash) will be obtained from the patient at the above time intervals. follow up visit will be scheduled 60days after the procedure for re-evaluation.

Conditions

  • Osteoarthritis, Knee

Interventions

DRUG

Methylprednisolone 40 MG Injection

Intra-articular knee injection will be performed in patient with knee osteoarthritis who meets inclusion criteria. After Random assignment Patient will either get Intra-articular Morphine with Bupivacaine or Depomedrol with Bupivacaine.

Sponsors & Collaborators

  • Henry Ford Health System

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-01-01
Primary Completion
2018-12-31
Completion
2018-12-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06163755 on ClinicalTrials.gov