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Microbiota Upper Respiratory Tract

NCT02933983 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 325

Last updated 2020-04-08

No results posted yet for this study

Summary

The aim of this study is to investigate whether the microbiota in the upper respiratory tract (URT) (nose, nasopharynx and sinuses) of chronic rhinosinusitis (CRS) patients is disturbed compared to healthy individuals. Therefore, bacterial DNA from swabs, aspirates and tissue will be isolated via commercially available DNA extraction kits, followed by Illumina MiSeq sequencing in order to identify the bacterial species present in these samples. Special attention will go to microbial species that are overrepresented in the healthy populations as potential health promoting microbes (i.e. probiotics). A better understanding of the URT microbiome might help us to better understand the pathology of CRS and might help to develop new microbiota-based strategies for CRS.

Conditions

  • Microbiota Upper Respiratory Tract

Interventions

OTHER

no intervention, compare URT microbiome healthy control group-chronic rhinosinusitis patients

Sponsors & Collaborators

  • University Hospital, Antwerp

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2015-05-31
Primary Completion
2018-08-24
Completion
2018-08-24

Countries

  • Belgium

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02933983 on ClinicalTrials.gov