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Procalcitonin Guided Antibiotic Therapy and Hospitalisation in Patients With Lower Respiratory Tract Infections: The "ProHOSP" Study

NCT00350987 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 1002

Last updated 2008-09-23

No results posted yet for this study

Summary

The aim of this study is to test if procalcitonin (PCT) guided antibiotic stewardship in patients with lower respiratory tract infection (LRTI) will be non-inferior, with at worst a 7.5% higher combined failure rate, as compared to standard care practice (current guidelines for LRTI) with reduced total antibiotic (AB) use and hospitalization rate and duration, respectively.

Conditions

  • Lower Respiratory Tract Infection
  • Pneumonia
  • Bronchitis

Interventions

BEHAVIORAL

a strategy based on PCT guided AB therapy

In this study a strategy based on PCT guided AB therapy with enforced guideline implementation will be compared.

Sponsors & Collaborators

  • University Hospital, Basel, Switzerland

    lead OTHER

Principal Investigators

  • Mjriam Christ-Crain, Dr.med. · University Hospital in Basel

  • Philipp Schuetz, Dr.med. · University Hospital in Basel

  • Werner Zimmerli, Prof. · University Hospital in Liestal, Switzerland

  • Beat Mueller, Prof. · University Hospital in Basel

Study Design

Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2006-10-31
Primary Completion
2008-06-30
Completion
2008-06-30

Countries

  • Switzerland

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT00350987 on ClinicalTrials.gov