Chloroquine for Patients With Symptomatic Persistent Atrial Fibrillation: A Prospective Pilot Study
NCT02932007 · Status: RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 40
Last updated 2019-08-19
Summary
The goal of this pilot study is to explore the efficacy of chloroquine in terminating persistent AF and assess its potential role as a pharmacological cardioversion agent for the management of AF.
Conditions
Interventions
- DRUG
-
Chloroquine Phosphate
Two tablets of study drug are to be taken on the day of study drug initiation and the next day, followed by one tablet each day for the next 12 days. Study drug to be orally administered and taken with food.
Sponsors & Collaborators
-
University of South Florida
lead OTHER
Principal Investigators
-
Sami Noujaim, PhD · University of South Florida
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2017-03-28
- Primary Completion
- 2020-03-31
- Completion
- 2020-09-30
- FDA Drug
- Yes
Countries
- United States
Study Locations
More Related Trials
-
Catheter Ablation for Atrial Fibrillation and Heart Failure
NCT01082601 ·Status: WITHDRAWN
-
Cardiac Resynchronization in Atrial Fibrillation Trial - a Pilot Study
NCT01850277 ·Status: UNKNOWN ·Phase: PHASE4
-
Impact of Colchicine Therapy on Arrhythmia Recurrence After Acute Pericardial Effusion
NCT02260206 ·Status: COMPLETED ·Phase: PHASE4
-
Pharmacogenetic Study of Antiarrhythmic Drugs for Atrial Fibrillation
NCT02347111 ·Status: RECRUITING ·Phase: PHASE4
-
The Safety and Efficacy of Pulsed Field Ablation for Patients With Persistent Atrial Fibrillation Comorbid With HFpEF.
NCT07077811 ·Status: ENROLLING_BY_INVITATION ·Phase: NA
-
Single Dose Flecainide for Early Sinus Rhythm Conversion of Perioperative Atrial Fibrillation After Noncardiac Surgery
NCT06142604 ·Status: WITHDRAWN ·Phase: PHASE4
-
Atrial Fibrillation and Congestive Heart Failure Trial
NCT00597077 ·Status: COMPLETED ·Phase: PHASE4
-
A Clinical Study of the Arctic Front Cryoablation Balloon for the Treatment of Paroxysmal Atrial Fibrillation
NCT00523978 ·Status: COMPLETED ·Phase: PHASE3
-
Early Treatment of Atrial Fibrillation for Stroke Prevention Trial in Acute STROKE
NCT05293080 ·Status: RECRUITING ·Phase: PHASE3
-
Beta-blockers for Prevention of Supraventricular Arrhythmia Following PFO Closure
NCT07123506 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
Efficacy and Safety Evaluation of Azimilide or Sotalol vs Placebo for Treatment of Patients With Atrial Fibrillation.
NCT00035451 ·Status: COMPLETED ·Phase: PHASE3
-
Radiofrequency Catheter Ablation for Chronic Atrial Fibrillation
NCT00272636 ·Status: COMPLETED ·Phase: NA
-
Reversal of Atrial Substrate to Prevent Atrial Fibrillation Pilot Study
NCT03186976 ·Status: COMPLETED ·Phase: NA
-
Antiarrhythmic Drugs Assessment in Preventing Atrial Fibrillation
NCT02145546 ·Status: UNKNOWN ·Phase: PHASE4
-
Atrial Fibrillation With Sinus Node Dysfunction: Intensive Device Follow-up
NCT03607123 ·Status: UNKNOWN
-
Study of RSD1235-SR for the Prevention of Atrial Fibrillation/Atrial Flutter Recurrence
NCT00267930 ·Status: COMPLETED ·Phase: PHASE2
-
Antazoline in Comparison to Propafenone in Pharmacological Cardioversion of Atrial Fibrillation.
NCT05720572 ·Status: RECRUITING ·Phase: PHASE4
-
Determination of Rates and Reasons for Non-Adherence to Anti-Arrhythmic Therapy for Atrial Fibrillation
NCT01513031 ·Status: TERMINATED ·Phase: PHASE4
-
Prospective Multicenter Randomized and Controlled Study Evaluating the Benefit of Early Pulmonary Vein Isolation Compared to Usual Treatment in Patients Aged Over 75 Years and Presenting With Atrial Fibrillation
NCT06322017 ·Status: RECRUITING ·Phase: NA
-
An Exploratory Study of Focal Pulse Ablation System in the Treatment of Atrial Arrhythmia
NCT06157437 ·Status: RECRUITING ·Phase: NA
-
Rhythm Control of AF in Patients With Acute Stroke
NCT02285387 ·Status: UNKNOWN ·Phase: NA
-
A Study of the Effectiveness of Anti-Arrhythmic Medications After Atrial Fibrillation Ablation
NCT00408200 ·Status: COMPLETED ·Phase: NA
-
Left Atrium Substrate Based Ablation Plus Circumferential Pulmonary Vein Isolation to Treat Chronic Atrial Fibrillation
NCT01716143 ·Status: UNKNOWN ·Phase: NA
-
Safety and Efficacy of CryoCor™ Cryoablation for PAF
NCT00231296 ·Status: COMPLETED ·Phase: NA
-
Efficacy of Different Ablation Strategies for Controlling Atrial Fibrillation
NCT00379301 ·Status: COMPLETED ·Phase: NA