Child Characteristics, Neuromarkers, and Intervention Components Impacting Treatment Outcome: CCT, TF-CBT, TAU

Summary

This study is designed to examine three treatment conditions for traumatized youth: Cue-Centered Treatment (CCT), Trauma-Focused Cognitive-Behavioral Therapy (TF-CBT), and Treatment as Usual (TAU) to determine which treatment works most effectively for which youth. The investigators would like to determine feasibility of training on the treatment interventions. In addition, this study aims to inform development of systems of care for chronically traumatized youth.

The investigators hope to determine whether 1) TF-CBT and CCT will have better outcomes than TAU, 2) Child characteristics predict better outcome in either TF-CBT or CCT and to identify which phases of treatment are most effective, and 3) Imaging findings will be predictors of improved outcome. This research is important because while there are many existing trauma interventions for youth, little is known about what is most essential in those interventions. This study will shed light on what components of treatment are most effective. Furthermore, there are minimal guidelines on how to select the most appropriate intervention for a particular child. This study will contribute to that knowledge by informing which interventions are suited best for which youth.

Conditions

• Stress Disorders, Post-Traumatic

Interventions

BEHAVIORAL

Cue-Centered Treatment (CCT)

Identify stress reactions and develop coping skills to deal with them independently. Helps address ongoing traumatic stressors.

BEHAVIORAL

Trauma-Focused CBT (TF-CBT)

Identifies negative cognitive/emotional patterns and helps re-frame them. Uses active support from guardians and focuses on emotional and cognitive conditioning. Focuses on discrete past incidents.

BEHAVIORAL

Treatment as Usual

The control group. The standard treatment utilized at Stanford Youth Solutions

DEVICE

NIRScout

The device is a portable Functional Near-Infrared Spectroscopy (fNIRS) recording unit. NIRS technology uses specific wavelengths of light, introduced at the scalp to enable the non-invasive measurement of changes in the relative ratios of deoxygenated hemoglobin (deoxy-Hb) and oxygenated hemoglobin (oxy-Hb) in the capillary beds during brain activity.

Sponsors & Collaborators

• Stanford Youth Solutions

  collaborator OTHER

• Drexel University

  collaborator OTHER

• Iowa State University

  collaborator OTHER

• University of California, San Francisco

  collaborator OTHER

• Stanford University

  lead OTHER

Principal Investigators

• Victor G Carrion, M.D. · Stanford University

• Hilit Kletter, PhD · Stanford University

• Flint Espil, PhD · Stanford Univeristy

Study Design

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Model

PARALLEL

Eligibility

Min Age

7 Years

Max Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-01-01

Primary Completion

2020-04-24

Completion

2020-04-24

Countries

• United States

Study Locations