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Physiology of Lung Collapse Under One-Lung Ventilation: Underlying Mechanisms

NCT02919267 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2020-05-26

Study results available
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Summary

Lung isolation technique and one-lung ventilation (OLV) are the mainstays of thoracic anesthesia. Two principal lung isolation techniques are mainly use by clinicians, the double lumen tubes (DLT) and the bronchial blockers (BB). The physiology of lung collapse during OLV is not well described in the literature. Few publications characterized scant aspects of lung collapse, only with the use of DLT and sometime in experimental animals. Two phases of lung collapse have been described. The first phase is a quick and partial secondary to the intrinsic recoil of the lung. The second phase is the reabsorption of gas contained in the alveoli by the capillary bed. The investigators plan to describe the physiology of the second phase of lung deflation using of DLT or BB, in a human clinical context.

Conditions

  • Lung Collapse
  • One-Lung Ventilation
  • Thoracic Surgery
  • Video-Assisted

Interventions

DEVICE

Double lumen tube

Either gaseous volume quantification or intrapulmonary pressure measurements will be done in patients randomized in the L-DLT group.

DEVICE

Bronchial blocker

Either gaseous volume quantification or intrapulmonary pressure measurements will be done in patients randomized in the BB group.

Sponsors & Collaborators

  • Laval University

    lead OTHER

Principal Investigators

  • Olivier Moreault, MD · Laval University

  • Jean S Bussières, MD · Laval University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2016-09-30
Primary Completion
2016-12-31
Completion
2016-12-31

Countries

  • Canada

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02919267 on ClinicalTrials.gov