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Platelet Function in Resuscitated Patients

NCT02914795 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 99

Last updated 2020-12-03

Study results available
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Summary

Approx. 65% of resuscitated patients at the intensive care unit for internal medicine are due to myocardial infarction. Almost all patients are initially diagnosed and treated in the cath lab. Therapy usually consists of one or more stent implantations. After implantation of a coronary stent, dual platelet inhibition is necessary for 12 months. Insufficient platelet inhibition causes an pronounced increase in risk of stent thrombosis. Therefore, knowledge of the individual platelet function is valuable.

Several factors potentially promote a delayed or reduced mode of action of platelet function inhibitors in resuscitated patients:

1. oral administration is impossible and medication needs to be administered via a gastric line.
2. gastric absorption is delayed after resuscitation
3. according to current guidelines patients are treated with therapeutic hypothermia. Including the time of rewarming cooling period is \~48h

Conditions

  • Acute ST Segment Elevation Myocardial Infarction

Interventions

OTHER

diagnostic analysis of platelet function

analysis of platelet aggregation using optical measurements as well as the commercial VerifyNow technique

Sponsors & Collaborators

  • Medical University of Graz

    lead OTHER

Principal Investigators

  • Dirk von Lewinski, MD · Medical University of Graz

Eligibility

Min Age
18 Years
Max Age
99 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2015-06-30
Primary Completion
2016-07-31
Completion
2016-08-31

Countries

  • Austria

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02914795 on ClinicalTrials.gov