Trial Outcomes & Findings for Platelet Function in Resuscitated Patients (NCT NCT02914795)
NCT ID: NCT02914795
Last Updated: 2020-12-03
Results Overview
Median (Inter-Quartile Range) Collagen AUC values on Day 3 measured with optical aggregometry The more light signal is detected, the better thrombocyte function is.
Recruitment status
COMPLETED
Target enrollment
99 participants
Primary outcome timeframe
day 3
Results posted on
2020-12-03
Participant Flow
Participant milestones
| Measure |
Non-resuscitated Myocardial Infarction
diagnostic analysis of platelet function of a matched historical cohort of the ATLANTIS-ACS trial
diagnostic analysis of platelet function: analysis of platelet aggregation using optical measurements as well as the commercial VerifyNow technique
|
Resuscitated Myocardial Infarction
diagnostic analysis of platelet function of the patient cohort included according to the inclusion criteria
diagnostic analysis of platelet function: analysis of platelet aggregation using optical measurements as well as the commercial VerifyNow technique
|
|---|---|---|
|
Overall Study
STARTED
|
77
|
22
|
|
Overall Study
COMPLETED
|
77
|
22
|
|
Overall Study
NOT COMPLETED
|
0
|
0
|
Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
Platelet Function in Resuscitated Patients
Baseline characteristics by cohort
| Measure |
Non-resuscitated Myocardial Infarction
n=77 Participants
diagnostic analysis of platelet function of a matched historical cohort of the ATLANTIS-ACS trial
diagnostic analysis of platelet function: analysis of platelet aggregation using optical measurements as well as the commercial VerifyNow technique
|
Resuscitated Myocardial Infarction
n=22 Participants
diagnostic analysis of platelet function of the patient cohort included according to the inclusion criteria
diagnostic analysis of platelet function: analysis of platelet aggregation using optical measurements as well as the commercial VerifyNow technique
|
Total
n=99 Participants
Total of all reporting groups
|
|---|---|---|---|
|
Age, Categorical
<=18 years
|
0 Participants
n=99 Participants
|
0 Participants
n=107 Participants
|
0 Participants
n=206 Participants
|
|
Age, Categorical
Between 18 and 65 years
|
39 Participants
n=99 Participants
|
13 Participants
n=107 Participants
|
52 Participants
n=206 Participants
|
|
Age, Categorical
>=65 years
|
38 Participants
n=99 Participants
|
9 Participants
n=107 Participants
|
47 Participants
n=206 Participants
|
|
Age, Continuous
|
64.3 years
n=99 Participants
|
65 years
n=107 Participants
|
64.5 years
n=206 Participants
|
|
Sex: Female, Male
Female
|
18 Participants
n=99 Participants
|
3 Participants
n=107 Participants
|
21 Participants
n=206 Participants
|
|
Sex: Female, Male
Male
|
59 Participants
n=99 Participants
|
19 Participants
n=107 Participants
|
78 Participants
n=206 Participants
|
|
Region of Enrollment
Austria
|
77 participants
n=99 Participants
|
22 participants
n=107 Participants
|
99 participants
n=206 Participants
|
|
Collagen AUC day 1
|
219 AU*min
n=99 Participants
|
69.5 AU*min
n=107 Participants
|
185.8 AU*min
n=206 Participants
|
PRIMARY outcome
Timeframe: day 3Median (Inter-Quartile Range) Collagen AUC values on Day 3 measured with optical aggregometry The more light signal is detected, the better thrombocyte function is.
Outcome measures
| Measure |
Non-resuscitated Myocardial Infarction
n=77 Participants
diagnostic analysis of platelet function of a matched historical cohort of the ATLANTIS-ACS trial
diagnostic analysis of platelet function: analysis of platelet aggregation using optical measurements
|
Resuscitated Myocardial Infarction
n=22 Participants
diagnostic analysis of platelet function of the patient cohort included according to the inclusion criteria
diagnostic analysis of platelet function: analysis of platelet aggregation using optical measurements
|
|---|---|---|
|
Platelet Inhibition Measured With Optical Aggregometry
|
109 AU*min
Interval 73.0 to 182.0
|
253.8 AU*min
Interval 122.7 to 352.2
|
SECONDARY outcome
Timeframe: 7 daysOutcome measures
| Measure |
Non-resuscitated Myocardial Infarction
n=77 Participants
diagnostic analysis of platelet function of a matched historical cohort of the ATLANTIS-ACS trial
diagnostic analysis of platelet function: analysis of platelet aggregation using optical measurements
|
Resuscitated Myocardial Infarction
n=22 Participants
diagnostic analysis of platelet function of the patient cohort included according to the inclusion criteria
diagnostic analysis of platelet function: analysis of platelet aggregation using optical measurements
|
|---|---|---|
|
Number of Participants With Cumulative Clinical Endpoint of Death and Stent Thrombosis
|
0 Participants
|
3 Participants
|
Adverse Events
Resuscitated MI
Serious events: 0 serious events
Other events: 0 other events
Deaths: 3 deaths
Non Resuscitated MI
Serious events: 0 serious events
Other events: 0 other events
Deaths: 0 deaths
Serious adverse events
| Measure |
Resuscitated MI
n=22 participants at risk
Death within the Observation period of 7 days; n=3
|
Non Resuscitated MI
n=77 participants at risk
Death within the Observation period of 7 days; n=0
|
|---|---|---|
|
Blood and lymphatic system disorders
High on aspirin platelet reactivity
|
0.00%
0/22 • 7 days
|
0.00%
0/77 • 7 days
|
Other adverse events
Adverse event data not reported
Additional Information
Assoc. Prof. Dr. Dirk von Lewinski
Medical University of Grazt
Phone: +43 316 385
Email: [email protected]
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place