MedTrace Logo

Proteomic Profiling of Coronary Thrombus in Acute Myocardial Infarction

NCT03731884 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 50

Last updated 2019-04-18

No results posted yet for this study

Summary

ST-elevation myocardial infarction (STEMI) is mostly caused by the rupture or the erosion of a vulnerable atherosclerotic plaque, initiating with intraluminal thrombosis and resulting in total occlusion of the coronary artery. Thrombus formation is a complex and dynamic process involving flow, blood cells and several plasma proteins, and it has not been clearly elucidated. To define - through proteomic approach - the composition of occluding thrombus and its time changes in patients with STEMI, trying to identify novel biomarkers of coronary thrombosis.

Conditions

  • Acute Myocardial Infarction
  • STEMI - ST Elevation Myocardial Infarction

Interventions

OTHER

Time from the onset of symptoms to PCI

Patients will be divided in two groups according to the time from the onset of symptoms to PCI

Sponsors & Collaborators

  • Azienda Sanitaria Locale n. 2 - Lanciano Vasto Chieti

    collaborator OTHER

  • Catholic University of the Sacred Heart

    collaborator OTHER

  • G. d'Annunzio University

    lead OTHER

Principal Investigators

  • Marco Zimarino, MD, PhD · G. D'Annunzio University. Institute of Cardiology

  • Damiana Pieragostino · Department of Medical, Oral and Biotechnological Sciences, G. d'Annunzio University - Chieti

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2017-01-01
Primary Completion
2019-12-31
Completion
2019-12-31

Countries

  • Italy

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03731884 on ClinicalTrials.gov